Excessively high soluble Klotho in patients with acromegaly
نویسندگان
چکیده
منابع مشابه
Excessively high soluble Klotho in patients with acromegaly.
OBJECTIVES Klotho-deficient mice develop a syndrome resembling accelerated ageing, and genetic variants of Klotho have been associated with human ageing. In humans, serum levels of soluble Klotho decrease with age and with chronic renal failure. The aim of our study was to examine the relationship between excess growth hormone (GH) and serum levels of Klotho in patients with acromegaly, a disea...
متن کاملSoluble Klotho protein as a novel serum biomarker in patients with acromegaly
Acromegaly is a chronic disease caused by overproduction of growth hormone, in most cases due to excessive secretion from a pituitary ad-enoma [1, 2]. The incidence of acromegaly is approximately 5 cases per million per year, and the prevalence is estimated to be about 60 cases per million [3]. Growth hormone (GH) induces the synthesis of insulin-like growth factor-1 (IGF-1), which leads to sev...
متن کاملGender dependence of serum soluble Klotho in acromegaly.
OBJECTIVES In acromegaly, disease activity is biochemically assessed by growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. However, they are often discrepant, as several factors including gender influence their relationship. We recently found excessively high serum levels of soluble Klotho (sKl) in acromegalic patients, which depended on GH to a comparable extent as IGF-1. To ...
متن کاملIn active acromegaly, IGF1 bioactivity is related to soluble Klotho levels and quality of life
The value of measuring IGF1 bioactivity in active acromegaly is unknown. Soluble Klotho (S-Klotho) level is elevated in active acromegaly and it has been suggested that S-Klotho can inhibit activation of the IGF1 receptor (IGF1R). A cross-sectional study was carried out in 15 patients with active acromegaly based on clinical presentation, unsuppressed GH during an oral glucose tolerance test, a...
متن کاملCholecalciferol supplementation reduces soluble Klotho concentration in hemodialysis patients.
INTRODUCTION Low levels of vitamin D are linked to numerous adverse clinical conditions in hemodialysis (HD) patients, including disturbances of mineral and bone metabolism and increased mortality. Klotho, a molecule involved in such processes as phosphate homeostasis and aging, exists in 2 forms: a transmembrane protein acting as a coreceptor for fibroblast growth factor 23 (FGF-23) and solubl...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2012
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.2012.02542.x